What is the primary mechanism by which thrombomodulin regulates coagulation, particularly in the context of protein C activation?

A By binding to and activating protein C ✓
B By inhibiting the activity of factor Xa
C By enhancing the activity of antithrombin III
D By promoting the formation of fibrin clots

Explanation

Thrombomodulin binds to thrombin and changes its activity from a procoagulant to an anticoagulant, facilitating the activation of protein C.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: high