What is the mechanism by which activated protein C regulates coagulation, particularly in relation to factors Va and VIIIa?

A It inhibits the activation of factors Va and VIIIa
B It enhances the activation of factors Va and VIIIa
C It has no effect on factors Va and VIIIa
D It degrades factors Va and VIIIa ✓

Explanation

Activated protein C acts as an anticoagulant by degrading factors Va and VIIIa, which are essential for the coagulation cascade.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: high