A patient with a coagulation disorder is found to have a mutation in the SERPINC1 gene. Which coagulation disorder is this patient likely to have?

A Antithrombin deficiency ✓
B Protein C deficiency
C Protein S deficiency
D Factor V Leiden mutation

Explanation

The SERPINC1 gene encodes for antithrombin, a protein that inhibits the activity of several coagulation factors, including thrombin and factor Xa. Mutations in this gene can lead to antithrombin deficiency, increasing the risk of venous thromboembolism.

Source

Genetic and molecular studies on coagulation disorders
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: high