What is the primary cause of thrombotic thrombocytopenic purpura, a coagulation disorder characterized by thrombocytopenia and microangiopathic hemolytic anemia?

A Deficiency of ADAMTS13 enzyme ✓
B Deficiency of von Willebrand factor
C Deficiency of factor VIII
D Deficiency of protein C

Explanation

Thrombotic thrombocytopenic purpura (TTP) is a rare blood disorder characterized by the formation of blood clots in small blood vessels throughout the body. The primary cause of TTP is a deficiency of the ADAMTS13 enzyme, which is responsible for cleaving and regulating von Willebrand factor.

Source

National Heart, Lung, and Blood Institute
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: high