Which coagulation factor is affected in patients with combined factor V and factor VIII deficiency?

A Factor X
B Factor IX
C LMAN1 gene product ✓
D Von Willebrand factor

Explanation

Combined factor V and factor VIII deficiency is a rare bleeding disorder caused by a deficiency of the LMAN1 gene product, which is necessary for the transport of these coagulation factors from the endoplasmic reticulum to the Golgi apparatus.

Source

Journal of Thrombosis and Haemostasis article
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: high