A patient with a history of easy bruising and prolonged bleeding after trauma is found to have a reduced level of high-molecular-weight von Willebrand factor multimers. What is the most likely diagnosis?
Explanation
Type 2B von Willebrand disease is characterized by a reduced level of high-molecular-weight von Willebrand factor multimers, leading to impaired platelet adhesion and increased risk of bleeding.
Source
New England Journal of Medicine, 2019