What is the primary function of protein C in the coagulation cascade?

A To activate factor X
B To inhibit the activation of factor V and factor VIII ✓
C To enhance the activation of factor XII
D To increase the production of thrombin

Explanation

Protein C is a vitamin K-dependent protein that plays a crucial role in regulating the coagulation cascade. It inhibits the activation of factor V and factor VIII, thereby preventing excessive thrombin generation and reducing the risk of thrombosis.

Source

Harrison's Principles of Internal Medicine
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Medium MEDICAL Confidence: high