Which of the following coagulation disorders is characterized by an autosomal dominant inheritance pattern and is caused by a mutation in the gene encoding the protein that regulates the activity of factor Va and factor VIIIa?

A Protein C deficiency
B Protein S deficiency
C Antithrombin III deficiency
D Factor V Leiden mutation ✓

Explanation

Factor V Leiden mutation is an autosomal dominant disorder caused by a mutation in the gene encoding factor V, which regulates the activity of factor Va and factor VIIIa.

Source

Harrison's Principles of Internal Medicine
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: high