A patient with a history of recurrent arterial thrombosis is found to have elevated levels of homocysteine in their blood. What is the most likely underlying cause of this condition?

A Deficiency of vitamin B12
B Deficiency of folate
C Mutation in the MTHFR gene
D All of the above ✓

Explanation

Elevated levels of homocysteine can be caused by deficiencies in vitamin B12 or folate, as well as mutations in the MTHFR gene, which is involved in homocysteine metabolism.

Source

Hematology textbooks and research articles
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Medium MEDICAL Confidence: high