A patient with anemia is found to have a low reticulocyte count, normal serum iron, and a elevated serum folate level. Which of the following is the most likely cause of this patient's anemia?

A Iron deficiency anemia
B Vitamin B12 deficiency anemia
C Anemia of chronic disease
D Pure red cell aplasia
The patient's low reticulocyte count and normal serum iron level suggest a production defect rather than a loss or destruction of red blood cells. The elevated serum folate level rules out folate deficiency as a cause. Pure red cell aplasia is a rare disorder characterized by a selective failure of erythropoiesis, which would explain the patient's low reticulocyte count and normal serum iron level.
Harrison's Principles of Internal Medicine
Hematology Hematology: Anemia Hematology: Anemia Hard MEDICAL Confidence: medium