A patient with chronic kidney disease is found to have a normocytic anemia. Which of the following is the most likely cause of this anemia?

A Decreased production of erythropoietin by the kidneys ✓
B Increased production of hepcidin due to inflammation
C Deficiency of vitamin B12 due to dietary restrictions
D Resistance to erythropoietin due to uremic toxins

Explanation

Chronic kidney disease often leads to a decrease in the production of erythropoietin, a hormone produced by the kidneys that stimulates red blood cell production in the bone marrow. This decrease can result in normocytic anemia.

Source

Harrison's Principles of Internal Medicine, 20th edition
Hematology Hematology: Anemia Hematology: Anemia Medium MEDICAL Confidence: high