A 30-year-old woman presents with anemia, jaundice, and splenomegaly. Laboratory tests reveal a hemoglobin level of 8 g/dL, a mean corpuscular volume (MCV) of 80 fL, and a reticulocyte count of 10%. What is the most likely diagnosis?

A Hereditary spherocytosis
B Autoimmune hemolytic anemia
C Thalassemia major
D Glucose-6-phosphate dehydrogenase deficiency
The combination of anemia, jaundice, and splenomegaly in a young adult is suggestive of a hemolytic anemia. The laboratory findings of a low hemoglobin level, normal MCV, and elevated reticulocyte count support this diagnosis. Hereditary spherocytosis is a congenital disorder characterized by the production of abnormal spherical red blood cells that are prone to premature destruction, leading to hemolytic anemia.
New England Journal of Medicine
Hematology Hematology: Anemia Hematology: Anemia Medium MEDICAL Confidence: high