Which blood component is responsible for the removal of senescent red blood cells from circulation?

A Macrophages in the spleen ✓
B Neutrophils in the liver
C Dendritic cells in the lymph nodes
D Eosinophils in the bone marrow

Explanation

Macrophages in the spleen recognize and remove senescent red blood cells from circulation, helping to maintain healthy erythrocyte populations.

Mnemonic

_SPLASH = Spleen Phagocytoses Late-Stage Aging Hemocytes

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Blood Components Hematology: Blood Components Hard MEDICAL Confidence: medium