Which of the following types of anemia is associated with a mutation in the HBB gene, leading to the production of abnormal hemoglobin?

A Thalassemia major
B Sickle cell disease ✓
C Hereditary spherocytosis
D Glucose-6-phosphate dehydrogenase deficiency

Explanation

Sickle cell disease is caused by a mutation in the HBB gene that codes for the beta-globin subunit of hemoglobin, resulting in the production of abnormal hemoglobin S.

Source

Genetics and Molecular Biology textbooks
Hematology Hematology: Anemia Hematology: Anemia Hard MEDICAL Confidence: high