What is the primary mechanism by which vitamin B12 deficiency leads to megaloblastic anemia?

A Impaired DNA synthesis ✓
B Increased red blood cell destruction
C Decreased iron absorption
D Abnormal hemoglobin production

Explanation

Vitamin B12 plays a crucial role in DNA synthesis, and its deficiency leads to impaired DNA synthesis, resulting in megaloblastic anemia.

Source

Harrison's Principles of Internal Medicine
Hematology Hematology: Anemia Hematology: Anemia Medium MEDICAL Confidence: high