What is the mechanism by which hepcidin regulates iron homeostasis in the body, particularly in the context of anemia?

A By increasing iron absorption in the gut
B By decreasing iron release from macrophages
C By inhibiting the production of erythropoietin
D By binding to ferroportin and inducing its internalization and degradation ✓

Explanation

Hepcidin plays a crucial role in regulating iron metabolism by binding to ferroportin, the only known iron exporter, leading to its internalization and degradation, thus reducing iron export from cells and decreasing plasma iron levels.

Source

Recent research articles on hepcidin and iron metabolism
Hematology Hematology: Anemia Hematology: Anemia Hard MEDICAL Confidence: high