What is the role of hypoxia-inducible factor 1 alpha (HIF-1α) in hematopoietic stem cell regulation?

A It inhibits the expression of genes involved in hematopoiesis
B It promotes the proliferation and survival of hematopoietic stem cells ✓
C It suppresses the differentiation of hematopoietic stem cells into mature blood cells
D It has no effect on hematopoietic stem cell regulation

Explanation

HIF-1α plays a crucial role in regulating hematopoietic stem cell function, particularly under hypoxic conditions. It promotes the proliferation and survival of hematopoietic stem cells by regulating the expression of genes involved in cell metabolism, angiogenesis, and apoptosis.

Source

Nature Reviews Immunology
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Hard MEDICAL Confidence: high