What is the function of the aryl hydrocarbon receptor (AhR) in hematopoietic stem cells?

A It regulates the expression of genes involved in cell cycle progression
B It modulates the activity of enzymes involved in heme synthesis
C It influences the migration and homing of hematopoietic stem cells to the bone marrow niche ✓
D It promotes the differentiation of hematopoietic stem cells into megakaryocytic lineage

Explanation

The aryl hydrocarbon receptor (AhR) plays a role in regulating the migration and homing of hematopoietic stem cells to the bone marrow niche, ensuring proper engraftment and function.

Source

Nature Reviews Immunology, Stockinger et al.
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Hard MEDICAL Confidence: medium