What is the role of hypoxia-inducible factor 1 alpha (HIF-1α) in the regulation of hematopoiesis?

A It inhibits the production of erythropoietin
B It promotes the proliferation of hematopoietic stem cells ✓
C It regulates the expression of genes involved in angiogenesis
D It suppresses the differentiation of hematopoietic progenitor cells

Explanation

HIF-1α plays a crucial role in regulating hematopoiesis by promoting the proliferation of hematopoietic stem cells and regulating the expression of genes involved in angiogenesis and erythropoiesis.

Source

Scientific literature on HIF-1α and hematopoiesis
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Hard MEDICAL Confidence: high