Which of the following transcription factors plays a crucial role in the development and maintenance of hematopoietic stem cells by regulating the expression of genes involved in self-renewal and differentiation?

A GATA1
B PU.1
C SCL/TAL1
D RUNX1 ✓

Explanation

RUNX1 is a transcription factor that plays a crucial role in the development and maintenance of hematopoietic stem cells by regulating the expression of genes involved in self-renewal and differentiation.

Source

Nature Reviews Immunology
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Hard MEDICAL Confidence: high