What is the role of Notch signaling in the regulation of hematopoietic stem cell fate?

A It promotes the differentiation of HSCs into mature blood cells ✓
B It inhibits the self-renewal of HSCs
C It maintains the quiescence of HSCs
D It regulates the homing of HSCs to the bone marrow niche

Explanation

Notch signaling plays a crucial role in regulating the fate of hematopoietic stem cells (HSCs) by promoting their differentiation into mature blood cells.

Source

Nature Reviews Immunology
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Hard MEDICAL Confidence: high