What is the role of osteoblasts in the hematopoietic stem cell niche?

A They produce granulocyte-colony stimulating factor (G-CSF)
B They regulate the expression of chemokines and cytokines
C They maintain the quiescence of hematopoietic stem cells ✓
D They promote the proliferation and differentiation of hematopoietic progenitor cells

Explanation

Osteoblasts play a crucial role in maintaining the quiescence of hematopoietic stem cells by producing factors that inhibit their proliferation and promote their survival.

Source

Nature Reviews Immunology
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Hard MEDICAL Confidence: high