What is the role of heparan sulfate proteoglycans in the hematopoietic stem cell niche?

A To inhibit hematopoietic stem cell proliferation
B To promote hematopoietic stem cell homing and retention ✓
C To suppress hematopoietic stem cell differentiation
D To induce hematopoietic stem cell apoptosis

Explanation

Heparan sulfate proteoglycans play a crucial role in the hematopoietic stem cell niche by promoting hematopoietic stem cell homing and retention, thereby regulating their behavior and fate.

Source

Scientific literature
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Hard MEDICAL Confidence: high