What is the primary mechanism by which hematopoietic stem cells maintain their quiescence and prevent premature differentiation?

A Cell cycle arrest ✓
B Apoptosis
C Autophagy
D Senescence

Explanation

Hematopoietic stem cells maintain their quiescence through cell cycle arrest, which prevents them from differentiating prematurely and allows them to retain their self-renewal capacity.

Source

Nature Reviews Immunology
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Hard MEDICAL Confidence: high