What is the primary mechanism by which hematopoietic stem cells maintain their quiescent state?

A Cell cycle arrest ✓
B Apoptosis
C Differentiation
D Proliferation

Explanation

Hematopoietic stem cells maintain their quiescent state primarily through cell cycle arrest, which allows them to remain dormant and retain their self-renewal capacity.

Source

Blood journal
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Hard MEDICAL Confidence: high