What is the role of hemoglobin's beta-globin subunit in determining the oxygen-binding affinity of hemoglobin?

A It increases the oxygen-binding affinity
B It decreases the oxygen-binding affinity ✓
C It has no effect on oxygen-binding affinity
D It is responsible for the binding of carbon dioxide

Explanation

The beta-globin subunit of hemoglobin plays a crucial role in determining the oxygen-binding affinity of hemoglobin. Mutations in the beta-globin gene can lead to changes in oxygen-binding affinity, resulting in conditions such as sickle cell anemia or beta-thalassemia.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Medium MEDICAL Confidence: high