What is the primary mechanism by which 2,3-bisphosphoglycerate regulates oxygen binding to hemoglobin?

A Increasing the affinity of hemoglobin for oxygen
B Decreasing the affinity of hemoglobin for oxygen ✓
C Increasing the rate of oxygen dissociation from hemoglobin
D Decreasing the rate of oxygen binding to hemoglobin

Explanation

2,3-bisphosphoglycerate binds to deoxyhemoglobin, stabilizing the T-state and decreasing the affinity of hemoglobin for oxygen, which facilitates oxygen release to tissues.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Medium MEDICAL Confidence: high