What is the primary mechanism by which carbon monoxide binds to hemoglobin, resulting in tissue hypoxia?

A Competitive inhibition of oxygen binding ✓
B Non-competitive inhibition of oxygen binding
C Allosteric modulation of hemoglobin
D Covalent modification of the heme group

Explanation

Carbon monoxide binds to hemoglobin with high affinity, displacing oxygen and reducing the amount of oxygen delivered to tissues.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Medium MEDICAL Confidence: high