How does methemoglobinemia affect the oxygen-binding properties of hemoglobin?

A It increases the affinity of hemoglobin for oxygen, leading to decreased oxygen delivery to tissues ✓
B It decreases the affinity of hemoglobin for oxygen, leading to increased oxygen delivery to tissues
C It has no effect on the oxygen-binding properties of hemoglobin, as methemoglobin cannot bind oxygen
D It shifts the oxygen-hemoglobin dissociation curve to the right, facilitating oxygen release to tissues

Explanation

Methemoglobinemia is a condition characterized by an abnormal amount of methemoglobin, a form of hemoglobin that cannot bind oxygen. This leads to a left-shift of the oxygen-hemoglobin dissociation curve, increasing the affinity of hemoglobin for oxygen and resulting in decreased oxygen delivery to tissues.

Source

Wintrobe's Clinical Hematology
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Hard MEDICAL Confidence: high