Which of the following hemoglobin variants is characterized by a decreased affinity for oxygen, resulting in increased oxygen delivery to tissues?

A Hemoglobin S (sickle hemoglobin)
B Hemoglobin C (beta-globin variant)
C Hemoglobin F (fetal hemoglobin)
D Hemoglobin Kansas (a rare beta-globin variant with low oxygen affinity) ✓

Explanation

Hemoglobin Kansas is a rare variant with decreased oxygen affinity, resulting in increased oxygen delivery to tissues.

Source

Orphanet Journal of Rare Diseases
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Hard MEDICAL Confidence: medium