How does the structure of hemoglobin influence its ability to facilitate oxygen transport in high-altitude environments?

A Increased affinity for oxygen due to lower pH
B Decreased affinity for oxygen due to higher pH
C Increased binding of 2,3-bisphosphoglycerate ✓
D Decreased binding of 2,3-bisphosphoglycerate

Explanation

At high altitudes, the lower oxygen levels lead to increased production of 2,3-bisphosphoglycerate, which binds to hemoglobin and decreases its affinity for oxygen, facilitating oxygen release to tissues.

Source

Physiology textbooks
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Hard MEDICAL Confidence: high