How does 2,3-Bisphosphoglycerate (2,3-BPG) affect the oxygen binding properties of hemoglobin?

A It increases the affinity of hemoglobin for oxygen
B It decreases the affinity of hemoglobin for oxygen ✓
C It has no effect on the oxygen binding properties of hemoglobin
D It only affects the binding of carbon dioxide to hemoglobin

Explanation

2,3-Bisphosphoglycerate (2,3-BPG) is an allosteric effector that binds to hemoglobin and decreases its affinity for oxygen, facilitating the release of oxygen to tissues.

Source

Biochemistry textbook by Stryer
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Medium MEDICAL Confidence: high