Which of the following factors influences the affinity of hemoglobin for oxygen in a manner that is not directly related to pH or carbon dioxide levels?

A Temperature
B 2,3-Bisphosphoglycerate levels ✓
C Glucose concentration
D Albumin binding

Explanation

2,3-Bisphosphoglycerate (2,3-BPG) is a molecule produced by red blood cells that binds to hemoglobin and reduces its oxygen affinity, facilitating the release of oxygen to tissues. This factor is not directly related to pH or carbon dioxide levels.

Source

Physiology and biochemistry texts
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Hard MEDICAL Confidence: high