Which of the following hemoglobinopathies is characterized by an abnormality in the production of the alpha-globin chains?

A Sickle cell disease
B Thalassemia ✓
C Hemoglobin C disease
D Hemoglobin E disease

Explanation

Thalassemia is a group of hemoglobinopathies characterized by an abnormality in the production of either the alpha-globin or beta-globin chains. Alpha-thalassemia specifically involves a deficiency or mutation in the genes that code for the alpha-globin chains.

Source

Robbins and Cotran Pathologic Basis of Disease
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Hard MEDICAL Confidence: high