Which of the following hemoglobin variants is characterized by a mutation that results in the substitution of glutamic acid for valine at position 6 of the beta-globin chain?
Explanation
The mutation that results in the substitution of glutamic acid for valine at position 6 of the beta-globin chain is responsible for sickle cell disease, which is caused by Hemoglobin S.
Mnemonic
'S' = 'sickle' → shaped like a sickle due to mutation
Source
Robbins and Cotran Pathologic Basis of Disease