What is the role of hemoglobin's beta-subunit in the regulation of oxygen transport?

A It increases the affinity of hemoglobin for oxygen
B It decreases the affinity of hemoglobin for oxygen
C It has no effect on the affinity of hemoglobin for oxygen
D It regulates the binding of carbon dioxide to hemoglobin
The beta-subunit of hemoglobin plays a crucial role in regulating oxygen transport by decreasing the affinity of hemoglobin for oxygen, allowing for the release of oxygen to tissues.
Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Medium MEDICAL Confidence: high