What is the mechanism by which hemoglobin's shape changes in response to oxygen binding, allowing for cooperative oxygen binding?

A Allosteric modulation
B Conformational change ✓
C Protein denaturation
D Electrostatic interactions

Explanation

Hemoglobin's shape changes in response to oxygen binding, allowing for cooperative oxygen binding, which is a conformational change.

Mnemonic

Conformation = Change in form → hemoglobin changes shape

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Medium MEDICAL Confidence: high