What is the role of 2,3-Bisphosphoglycerate in hemoglobin's oxygen transport function?

A It increases the affinity of hemoglobin for oxygen
B It decreases the affinity of hemoglobin for oxygen ✓
C It has no effect on the affinity of hemoglobin for oxygen
D It increases the rate of oxygen release from hemoglobin

Explanation

2,3-Bisphosphoglycerate is an allosteric effector that binds to hemoglobin and decreases its affinity for oxygen, allowing for more efficient release of oxygen to tissues.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Medium MEDICAL Confidence: high