Which of the following is a consequence of a mutation in the gene encoding the beta-globin subunit of hemoglobin, leading to the production of a dysfunctional protein?

A Sickle cell disease
B Thalassemia major ✓
C Hereditary spherocytosis
D Glucose-6-phosphate dehydrogenase deficiency

Explanation

Mutations in the gene encoding the beta-globin subunit can lead to the production of a dysfunctional protein, resulting in thalassemia major.

Source

Robbins and Cotran Pathologic Basis of Disease
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Hard MEDICAL Confidence: high