What is the effect of an increase in 2,3-Bisphosphoglycerate (2,3-BPG) on hemoglobin's oxygen-binding affinity?

A Increases oxygen-binding affinity
B Decreases oxygen-binding affinity ✓
C Has no effect on oxygen-binding affinity
D Enhances oxygen release to tissues

Explanation

2,3-Bisphosphoglycerate (2,3-BPG) is a molecule found in red blood cells that binds to hemoglobin and decreases its oxygen-binding affinity, facilitating the release of oxygen to tissues.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Medium MEDICAL Confidence: high