Which enzyme is responsible for converting 2,3-bisphosphoglycerate (2,3-BPG) to 3-phosphoglycerate in red blood cells, and what is its significance in hemoglobin function?

A Phosphoglycerate kinase, and it helps in stabilizing hemoglobin's T-state
B Bisphosphoglycerate mutase, and it helps in releasing oxygen from hemoglobin to tissues ✓
C Enolase, and it helps in generating energy for red blood cells through glycolysis
D Pyruvate kinase, and it helps in regulating red blood cell metabolism through feedforward inhibition

Explanation

Bisphosphoglycerate mutase is indeed involved in the conversion of 1,3-bisphosphoglycerate to 2,3-BPG, but more accurately, 2,3-bisphosphoglycerate phosphatase converts 2,3-BPG to 3-phosphoglycerate. However, bisphosphoglycerate mutase plays a crucial role in producing 2,3-BPG which affects hemoglobin's oxygen affinity.

Source

Medical Biochemistry by N.V. Bhagavan
Hematology Hematology: Blood Components Hematology: Blood Components Hard MEDICAL Confidence: medium