Which blood component is primarily responsible for the removal of old, damaged red blood cells from the circulation?

A Neutrophils
B Monocytes
C Macrophages in the spleen ✓
D Dendritic cells

Explanation

Macrophages in the spleen are primarily responsible for removing old, damaged red blood cells from the circulation. They recognize and engulf these cells, helping to maintain the quality and integrity of the red blood cell population.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Blood Components Hematology: Blood Components Easy MEDICAL Confidence: high