What is the primary role of heparan sulfate in the coagulation cascade?

A To activate factor XII
B To inhibit thrombin formation
C To bind and activate antithrombin III ✓
D To enhance fibrinolysis

Explanation

Heparan sulfate binds and activates antithrombin III, which then inhibits thrombin and other coagulation factors, thereby regulating the coagulation cascade.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Blood Components Hematology: Blood Components Medium MEDICAL Confidence: high