What is the primary mechanism by which erythropoiesis is regulated in the body?

A Negative feedback loop involving erythropoietin and oxygen levels ✓
B Positive feedback loop involving thrombopoietin and platelet count
C Paracrine signaling involving granulocyte-colony stimulating factor
D Autocrine signaling involving interleukin-3

Explanation

Erythropoiesis is regulated by a negative feedback loop involving erythropoietin, which is produced in response to low oxygen levels and stimulates the production of red blood cells.

Mnemonic

EPO = Erythropoietin, 'o' for oxygen

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Blood Components Hematology: Blood Components Medium MEDICAL Confidence: high