What is the primary role of heparan sulfate in the blood coagulation cascade?

A To activate factor XII
B To inhibit thrombin activity
C To bind and activate antithrombin III ✓
D To stimulate platelet aggregation

Explanation

Heparan sulfate plays a crucial role in binding and activating antithrombin III, which in turn inhibits the activity of several coagulation factors, including thrombin.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Blood Components Hematology: Blood Components Medium MEDICAL Confidence: high