A patient with severe diarrhea develops a condition characterized by a low serum bicarbonate level and a high anion gap. What is the most likely cause of this condition?

A Lactic acidosis
B Diabetic ketoacidosis
C Renal tubular acidosis
D Gastrointestinal bicarbonate loss ✓

Explanation

Severe diarrhea can lead to a significant loss of bicarbonate ions from the gut, resulting in a low serum bicarbonate level and a high anion gap.

Source

Harrison's Principles of Internal Medicine
Electrolytes and Acid-Base Balance Pathophysiology Acid-Base Disorders Hard MEDICAL Confidence: high