Which enzyme is involved in the degradation of homocysteine and its deficiency is associated with hyperhomocysteinemia?

A Cystathionine beta-synthase ✓
B Methionine synthase
C Betaine-homocysteine methyltransferase
D Homocysteine thiolactone hydrolase

Explanation

Cystathionine beta-synthase is an enzyme that catalyzes the conversion of homocysteine to cystathionine. A deficiency in this enzyme can lead to hyperhomocysteinemia, which is a risk factor for cardiovascular disease and other disorders.

Source

OMIM database
Enzymes in Disease Biochemistry Amino acid metabolism Medium MEDICAL Confidence: high