Which enzyme's deficiency is associated with an increased risk of cardiovascular disease due to elevated homocysteine levels?

A Methionine synthase
B Cystathionine beta-synthase
C Methylene tetrahydrofolate reductase ✓
D Dihydrofolate reductase

Explanation

Methylene tetrahydrofolate reductase (MTHFR) is an enzyme involved in the metabolism of homocysteine. Deficiency or mutations in the MTHFR gene can lead to elevated homocysteine levels, increasing the risk of cardiovascular disease.

Source

American Heart Association
Enzymes in Disease Biochemistry Amino Acid Metabolism Hard MEDICAL Confidence: high