Which enzyme's abnormal activity is associated with the development of Gaucher's disease, a lysosomal storage disorder characterized by the accumulation of glucocerebroside in cells?

A Acid lipase
B Glucocerebrosidase ✓
C Sphingomyelinase
D Hexosaminidase A

Explanation

Glucocerebrosidase is the enzyme responsible for breaking down glucocerebroside. Its deficiency or abnormal activity leads to Gaucher's disease, a lysosomal storage disorder.

Mnemonic

_G = Glucocerebrosidase, key to Gaucher's disease

Source

Scriver's The Metabolic and Molecular Bases of Inherited Disease
Enzymes in Disease Biochemistry Lysosomal Storage Disorders Hard MEDICAL Confidence: high