What is the primary enzyme responsible for the breakdown of glycogen to glucose in the liver, and its deficiency leads to a condition known as Von Gierke's disease?

A Glucokinase
B Glucose-6-phosphatase ✓
C Phosphofructokinase
D Fructose-1,6-bisphosphatase

Explanation

Glucose-6-phosphatase is the primary enzyme responsible for the breakdown of glycogen to glucose in the liver. Its deficiency leads to Von Gierke's disease, a type of glycogen storage disorder.

Mnemonic

G-6-P = Glucose-6-phosphatase, key to glycogen breakdown

Source

Harper's Biochemistry
Enzymes in Disease Biochemistry Glycogen Metabolism Disorders Medium MEDICAL Confidence: high